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Paul C. Wang, Ph.D.

Paul C. Wang, Ph.D. [pwang@howard.edu] [biosketch]
Director, Molecular Imaging Laboratory
Professor, Department of Radiology
Adjunct Professor, Department of Biochemistry and Molecular Biology
Howard University, College of Medicine

B.S. Physics, Fu Jen Catholic University, Taipei, Taiwan, 1974
M.S. Physics, University of Rhode Island, Kingston, RI, 1976
Ph.D. Applied Radiation Physics, MIT, 1982

Office
Cancer Center, Rm B112
Howard University Hospital
2041 Georgia Ave., NW
Washington, DC 20060

Research Statement

The Molecular Imaging Laboratory research focuses on in vivo imaging using MRI, and optical fluorescent and bioluminescent imaging. Particularly, we are interested using the molecular imaging techniques in studying: mechanisms of image contrast enhancement, improvement of sensitivity and specificity of tumor detection, and applications of diagnostics using small diseased animal models.

Selected Publication

  • McDonald MA, Wang PC, Siegel EL. Protein Nanospheres: Synergistic Nanoplatform-Based Probes for Multimodality Imaging, Proc. of SPIE (7910)79101G-1-17, 2011. [pdf]
  • Wang TX, Sridhar R, Korotcov A, Ting AH, Francis K, Mitchell J, Wang PC. Synthesis of Amphiphilic Triblock Copolymers as Multidentate Ligands for Biocompatible Coating of Quantum Dots. Colloids Surf A Physicochem Eng Asp. 375:147-155. 2011 [pdf]
  • Guo ST, Huang YY, Wei T, Zhang WD, Wang WW, Lin DS, Zhang X, Kumar A, Du Q, Xing JF, Deng LD, Liang ZC, Wang PC, Dong AJ, Liang XJ. Amphiphilic and Biodegradable Methoxy Polyethylene Glycol-block(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an Effective Gene Carrier. Biomaterials. 32(3):879-90. 2011 [pdf]
  • Meng J, Wang DL, Wang PC, Lee J, Chen CY, Liang XJ. Biomedical Activities of Endohedral Metallofullerene Optimized For Nanopharmaceutics. J Nanosci Nanotechnol. 10(12):8610-6, 2010 [pdf]
  • Guo ST, Huang YY, Jiang Q, Sun Y, Deng LD, Liang ZC, Du Q, Xing JF, Zhao YL, Wang PC, Dong AJ, Liang XJ. Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte. ACS Nano. 4(9):5505-5511, 2010 [pdf]
  • Ma H, Wang PC, Qian F, Liang XJ. Biological Effects of  Nanomaterials and Drugs Measured by Small Animal SPECT/CT Imaging System In Vivo. ACTA Biophysica Sinica 26(8):209-215, 2010. [pdf]
  • Liang XJ, Meng H, Wang YZ, He HY, Meng J, Lu J, Wang PC, Zhao YL, Gao XY, Sun BY, Chen CY, Xing GM, Shen DW, Wu Y, Yin JJ, Jia L. Metallofullerene Nanoparticles Circumvent Tumor Resistance to Cisplatin by Reactivating Endocytosis. Proc Natl Acad Sci. 107(16):7449-7454, 2010 [pdf]
  • Korotcov A, Shan L, Meng H, Wang TX, Sridhar R, Zhao YL, Liang XJ, Wang PC. A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for MRI Dynamic Contrast Enhancement Study, J Nanosci Nanotechnol. 10(11):7545-7549. 2010 [pdf]
  • Liang XJ, Chen C, Zhao YL, Wang PC. Circumventing Tumor Resistance to Chemotherapy by Nanotechnology. Multi-Drug Resistance in Cancer, Methods in Molecular Biology vol 596:467-488, 2010 [pdf]
  • Wang PC, Blumenthal RP, Zhao YL, Schneider JA, Miller N, Grodzinski P, Gottesman MM, Tinkle S, Wang K, Wang C, Liang XJ. Building Scientific Progress Without Borders: Nanobiology and Nanomedicine in China and the U.S. Cancer Research, , Cancer Research 69(13);5294-5295, 2009 [pdf]
  • Hao YB, Xie TP, Korotcov A, Zhou YF, Pang XW, Guo YH, Ji HG, Shan L, Wang PC, Califano J, Xinbin Gu XB. Salvianolic Acid B Inhibits Growth of Head and Neck Squamous Cell Carcinoma in vitro and in vivo via Cyclooxygenase-2 and Apoptotic Pathways. Int J Cancer 124(9):2200-2209, 2009 [pdf]
  • Yin JJ, Lao F, Fu PP, Wamer WG, Zhao YL, Wang PC, Han D , Qin Y, Sun BY, Xing GM, Dong JQ, Liang XJ, Chen CY. The Scavenging of Reactive Oxygen Species and the Potential for Cell Protection by Functionalized Fullerene Materials. Biomaterials. 30(4):611-621, 2009 [pdf]
  • Liang XJ, Chen CY, Zhao YL, Jia L, Wang PC. Biopharmaceutics and Therapeutic Potential of Engineered Nanoparticles. Curr Drug Metab. 9(8):697-709, 2008 [pdf]
  • Wang PC, Shan L, Wang SP, Korotcov A, Liang XJ. Transferrin Liposome Nanoparticle (TfNIR-LipNBD-Magnevist) – A Tumor Targeting MRI Contrast Agent. Acta Biophysica Sinica 24(4):315-322, 2008 [pdf]
  • Shan L, Zhang RS, Zhang WH, Lee E, Sridhar R, Snyderwine EG, Wang PC. Image-based Real-time Evaluation of the Molecular Events Underlying HC11 Mammary Epithelial Cell Differentiation. Anal Biochem 382:122-128, 2008 [pdf]
  • Yin JJ, Lao F, Meng J, Fu PP, Zhao YL, Xing GM, Gao XY, Sun BY, Wang PC, Chen CY, and Liang XJ. Inhibition of Tumor Growth by Endohedral Metallofullerenol Nanoparticles Optimized as Reactive Oxygen Species Scavenger. Mol Pharmacol. 74(4):1132-1140, 2008 [pdf]
  • Shan L, Hao Y, Wang S, Korotcov A, Zhang R, Wang T, Califano J, Gu X, Sridhar R, Bhujwalla ZM, Wang PC. Visualizing Head and Neck Tumors In Vivo Using Near-infrared Fluorescent Transferrin Conjugate. Mol Imaging 7:42-49, 2008 [pdf]
  • Liang Shan, Songping Wang, Alexandru Korotcov, Rajagopalan Sridhar, Paul C. Wang. Bioluminescent Animal Models of Human Breast Cancer for Tumor Biomass Evaluation and Metastasis Detection.Ethn Dis 18:S2-65-69, 2008 [pdf]
  • Ross, S, Ejofodomi O, Jendoubi A, Kinnard L, Chouikha M, Lo B, Wang P, Zheng J. A Mammography Database and View System for the African American Patients. J Dig Imaging 21:18-26, 2008 [pdf]
  • Cheng KT, Wang PC, and Shan L. Alexa Fluor 680-labeled Transferrin-cationic (NBD-labeled DOPE-DOTAP) Liposome-encapsulated Gadopentetate Dimeglumine Complex (Abbreviated name: TfNIR-LipNBD-CA complex) Targeting to Transferrin Receptors (TfR). In: Molecular Imaging and Contrast Agent Database (MICAD) [database online]. National Library of Medicine (US), NCBI; 2008 http://micad.nih.gov
  • Shan L, Wang S, Sridhar R, Bhujwalla ZM, Wang PC. Dual Probe with Fluorescent and Magnetic Properties for Imaging Solid Tumor Xenografts. Molecular Imaging 6(2)85-95, 2007 [pdf]
  • Manaye KF, Wang PC, O'Neil JN, Tizabi Y, Lei D, Xu T, Huang SY, Ottinger MA, Ingram DK, Mouton PR. Neuropathological Quantification of Dtg APP/PS1: Neuroimaging, Stereology, and Biochemistry. AGE, 2007; 29:87-96, 2007 [pdf]
  • Pirollo K, Dagata J, Wang PC, Freedman M, Vladar A, Fricke S, Ileva L, Zhou Q, Chang EH. A Tumor-Targeted Nanodelivery System to Improve Early MRI Detection of Cancer. Molecular Imaging 5(1):41-52, 2006 [pdf]
  • Liang XJ, Yin JJ, Zhou JW, Wang PC, Taylor B, Cardarelli C, Kozar M, Forte R, Aszalos A, Gottesman M. Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells. Exp Cell Res 293:283-291, 2004 [pdf]
  • Kinnard L, Lo SB, Makariou E, Osicka T, Wang P, Chouikha MF, Freedman MT. Steepest changes of a probability-based cost function for delineation of mammographic masses: A validation study. Med. Phys. 31(10):2796-2810, 2004 [pdf]
  • Roh, MS, Bentz JA, Wang PC, Li EC, Koshioka M. Maturity and Temperature Stratification Affects the Germination of Styrax japonicus Seeds. J. Horticultural Sci. Biotech. Vol. 79, No. 4, July 2004 [pdf]
  • Scholz AM, Mitchell AD, Wang PC, Song HF. Accuracy of Volume Measurements by Magnetic Resonance Imaging. J. Anim. Sci. 79:1800-1813, 2001 [pdf]
  • Faust M, Wang PC, Maas J. The Use of Magnetic Resonance Imaging in Plant Science. Horticultural Review. vol 20, pp. 225-266, 1997 [pdf]
  • Chen CN, Wang PC, Song HF, Liu YC and Chen CS. Non-invasive Detection of Ibuprofen in vivo 13C NMR Signals in Rats. Chem Pharm Bull.44(1)204-207, 1996 [pdf]