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Magnetic Resonanse Imaging

The laboratory has two state-of-art NMR machines: a Varian 4.7 Tesla (200 MHz), 33 cm horizontal bore MRI/MRS system and a Bruker 9.4 Tesla (400 MHz), 89 mm vertical bore MRI/MRS system. Both MRI/MRS systems are capable of performing MRI as well as spectroscopy studies. The NMR laboratory has Sun workstations, a server and several personal computers for spectroscopy data and image processing. All the computers are networked together and linked to the university computer center.

	Varian 4.7 Tesla (200 MHz), 33 cm horizontal bore MRI/MRS system
	Bruker 9.4 Tesla (400 MHz), 89 mm vertical bore MRI/MRS system

Magnetic Resonanse Images DEMO library

A mouse tumor (MDA-MB-231 solid tumor xenograft marked with arrow) visualized using Dynamic Contrast Enhanced MRI with Magnevist (upper row) and a targeted (Transferrin-Liposome-Magnevist) nanocomplex (lower row). The targeted nanocomplex exhibited a stronger and heterogeneous signal enhancement.

In vivo (upper row) and ex vivo (lower row) normal mouse brain images visualized using a high resolution T2 weighted fast spin-echo MRI sequence. This sequence is designed to detect Alzheimer’s pathology (amyloid plaques) in the brains and spinal cords of transgenic mice, which become detectable by MRI at 6-8 months of disease progression.

A mouse aortic arch imaged using high resolution MRI to characterize the hemodynamic environment of the aortic arch.