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Research

Laboratory Director

Paul C. Wang, Ph.D. [pwang@howard.edu]
Director
Molecular Imaging Laboratory
Professor, Department of Radiology
Adjunct Professor, Department of Biochemistry and Molecular Biology
Howard University, College of Medicine

Research Statement

The Molecular Imaging Laboratory research focuses on in vivo imaging using MRI, and optical fluorescent and bioluminescent imaging. Particularly, we are interested using the molecular imaging techniques in studying: mechanisms of image contrast enhancement, improvement of sensitivity and specificity of tumor detection, and applications of diagnostics using small diseased animal models.

Research Projects

  • MR Image Enhancement by Tumor Cell Targeted Immunoliposome Complex Delivered Contrast Agent
  • Imaging the Effects of Macrophage Function on Tumor Promotion
  • NMR Studies of Phosphorus Metabolites of Breast Cancer Cells Using an Improved Cell Perfusion System
  • F19 NMR Detection of Trifluoperazine Crossing Blood-Brain-Barrier Through Pgp Modulation
  • Tumor-targeted MR Contrast Enhancement by Anti-transferrin Receptor scFv-Immunoliposome Nanoparticles
  • Enhanced Molecular Imaging with Fused Optical and MRI Images

Selected publications

  • Shan L, Wang S, Sridhar R, Bhujwalla ZM, Wang PC. Dual Probe with Fluorescent and Magnetic Properties for Imaging Solid Tumor Xenografts. Molecular Imaging 6(2)85-95, 2007 [pdf]
  • Liang Shan, Songping Wang, Alexandru Korotcov, Rajagopalan Sridhar, Paul C. Wang. Bioluminescent Animal Models of Human Breast Cancer for Tumor Biomass Evaluation and Metastasis Detection. Ethnicity & Disease, 2007 (in press) [pdf]
  • Manaye KF, Wang PC, O'Neil JN, Tizabi Y, Lei D, Xu T, Huang SY, Ottinger MA, Ingram DK, Mouton PR. Neuropathological Quantification of Dtg APP/PS1: Neuroimaging, Stereology, and Biochemistry. AGE, 2007 (in press) [pdf]
  • Ross S, Ejofodomi O'tega, Jendoubi A, Kinnard L, Chouika M, Lo B, Wang P, Zeng J. A Mammography Database and View System for African-American Patients. Journal of Digital Imaging, 2007 (in press) [pdf]
  • Pirollo K, Dagata J, Wang PC, Freedman M, Vladar A, Fricke S, Ileva L, Zhou Q, Chang EH. A Tumor-Targeted Nanodelivery System to Improve Early MRI Detection of Cancer. Molecular Imaging 5(1):41-52, 2006 [pdf]
  • Liang XJ, Yin JJ, Zhou JW, Wang PC, Taylor B, Cardarelli C, Kozar M, Forte R, Aszalos A, Gottesman M. Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells. Exp Cell Res 293:283-291, 2004 [pdf]
  • Kinnard L, Lo SB, Makariou E, Osicka T, Wang P, Chouikha MF, Freedman MT. Steepest changes of a probability-based cost function for delineation of mammographic masses: A validation study. Med. Phys. 31(10):2796-2810, 2004 [pdf]
  • Roh, MS, Bentz JA, Wang PC, Li EC, Koshioka M. Maturity and Temperature Stratification Affects the Germination of Styrax japonicus Seeds. J. Horticultural Sci. Biotech. Vol. 79, No. 4, July 2004 [pdf]
  • Scholz AM, Mitchell AD, Wang PC, Song HF. Accuracy of Volume Measurements by Magnetic Resonance Imaging. J. Anim. Sci. 79:1800-1813, 2001 [pdf]