Advancing Computational Biology @ Howard University - Seminar Series

Genome-Wide Mapping and Functional Impacts of Structural Variations in Cucumber Populations

November 20, 2014
4:00pm - 5:00pm
Seeley G. Mudd Building, Room 211

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Genome-Wide Mapping and Functional Impacts of Structural Variations in Cucumber Populations


Linyong Mao Ph.D.
Boyce Thompson Institute for Plant Research,
Cornell University, Ithaca, New York

Abstract

Structural variations (SVs) represent a major resource of genetic diversity. A nucleotide-resolution SV map of cucumber had been generated by population-scale genome sequencing. It allows a systematic investigation of SVís formation mechanisms and their functional impacts. Based on the map a copy number variation (CNV) has been discovered that defines the Female (F) locus and gives rise to gynoecious cucumber plants, which can set fruit at almost every node. The CNV arose from a 30.2-kb duplication via microhomology-mediated break-induced replication. F was quickly adopted in highly productive greenhouse cultivation, providing an example of a new plant CNV successfully exploited in modern agriculture.